Physical Chemistry, an upper-level course for Chemistry and Biochemistry majors, revisits topics from General Chemistry with mathematical rigor and deeper insight. The course seeks to answer four central questions key in the study of Chemistry:  (1) How do we describe matter? (2) How do we study and characterize matter? (3) What is the direction of chemical change? (4) How fast does chemical change occur?  Each question is answered respectively from the perspective of Physical Chemistry by (1) Quantum Mechanics, (2) Spectroscopy, (3) Thermochemistry & Equilibrium, and (4) Kinetics. An emphasis will be made in relating these topics to applications in understanding chemical and biological systems.